Assay Detail
Binding
CHEMBL5364825
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IL-23 induced STAT3 phosphorylation in human KIT225 cells by AlphaLISA assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KIT225 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Signal transducer and activator of transcription 3 (CHEMBL4026) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Progress on the Pharmacological Targeting of Janus Pseudokinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.87 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4469750 | — | — | 1 | 7.89 |
| CHEMBL4444178 | — | — | 1 | 7.82 |
| CHEMBL4435170 | DEUCRAVACITINIB | 4.0 | 1 | 7.05 |
| CHEMBL4561663 | — | — | 1 | 6.75 |
| CHEMBL4526283 | — | — | 1 | 6.64 |
| CHEMBL4289149 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4469750 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4444178 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4435170 | DEUCRAVACITINIB | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4561663 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4526283 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4289149 | — | IC50 | = | 8200.0 | nM | 5.09 |