Assay Detail
Binding
CHEMBL5364845
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to NSD2 PWWP1 domain (unknown origin) assessed as dissociation constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase NSD2 (CHEMBL3108645) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.58 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416709 | — | — | 1 | 7.34 |
| CHEMBL5200945 | — | — | 1 | 7.04 |
| CHEMBL4758943 | — | — | 1 | 6.46 |
| CHEMBL5401805 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416709 | — | Kd | = | 46.0 | nM | 7.34 |
| CHEMBL5200945 | — | Kd | = | 91.0 | nM | 7.04 |
| CHEMBL4758943 | — | Kd | = | 349.0 | nM | 6.46 |
| CHEMBL5401805 | — | Kd | = | 3400.0 | nM | 5.47 |