Assay Detail
Binding
CHEMBL5364868
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NSD3 degradation in human KMS-11 cells assessed as reduction in H3K36me2 levels by FRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | KMS-11 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase NSD3 (CHEMBL3108646) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.00 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438312 | — | — | 1 | 9.00 |
| CHEMBL5408212 | — | — | 1 | 9.00 |
| CHEMBL5396709 | — | — | 1 | 9.00 |
| CHEMBL5419719 | — | — | 1 | 9.00 |
| CHEMBL5432302 | — | — | 1 | 9.00 |
| CHEMBL5425629 | — | — | 1 | 9.00 |
| CHEMBL5433029 | — | — | 1 | 9.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438312 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5408212 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5396709 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5419719 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5432302 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5425629 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5433029 | — | IC50 | = | 1.0 | nM | 9.00 |