Assay Detail
Binding
CHEMBL5364873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to NSD1 (unknown origin) assessed as dissociation constant by ITC assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase, H3 lysine-36 specific (CHEMBL3588738) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Drug Discovery Targeting Nuclear Receptor Binding SET Domain Protein 2 (NSD2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.70 | 5.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438496 | — | — | 1 | 5.92 |
| CHEMBL554190 | QUINACRINE DIHYDROCHLORIDE | — | 1 | 5.85 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | 4.0 | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438496 | — | Kd | = | 1200.0 | nM | 5.92 |
| CHEMBL554190 | QUINACRINE DIHYDROCHLORIDE | Kd | = | 1400.0 | nM | 5.85 |
| CHEMBL58510 | CHLOROQUINE PHOSPHATE | Kd | = | 4700.0 | nM | 5.33 |