Assay Detail
Functional
CHEMBL5365107
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitumor activity against CHO cells expressing PCFT (R2/PCFT4) transporter assessed as inhibition of cell growth measured upto 96 hrs by Cell titer blue assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.77 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225072 | PEMETREXED | 4.0 | 1 | 7.88 |
| CHEMBL5408906 | — | — | 1 | 7.01 |
| CHEMBL5431881 | — | — | 1 | 6.72 |
| CHEMBL5432700 | — | — | 1 | 6.37 |
| CHEMBL5405010 | — | — | 1 | 6.32 |
| CHEMBL5418034 | — | — | 1 | 6.30 |
| CHEMBL5417651 | — | — | 1 | - |
| CHEMBL5438587 | — | — | 1 | - |
| CHEMBL5440815 | — | — | 1 | - |
| CHEMBL5421259 | — | — | 1 | - |
| CHEMBL5402700 | — | — | 1 | - |
| CHEMBL5429283 | — | — | 1 | - |
| CHEMBL5427804 | — | — | 1 | - |
| CHEMBL5431331 | — | — | 1 | - |
| CHEMBL5415985 | — | — | 1 | - |
| CHEMBL5400671 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225072 | PEMETREXED | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL5408906 | — | IC50 | = | 98.05 | nM | 7.01 |
| CHEMBL5431881 | — | IC50 | = | 191.4 | nM | 6.72 |
| CHEMBL5432700 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL5405010 | — | IC50 | = | 479.17 | nM | 6.32 |
| CHEMBL5418034 | — | IC50 | = | 497.07 | nM | 6.30 |
| CHEMBL5417651 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5438587 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5440815 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5421259 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5402700 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5429283 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5427804 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5431331 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5415985 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5400671 | — | IC50 | > | 1000.0 | nM | - |