Assay Detail
Functional
CHEMBL5365320
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Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by Celltiter-glo luminescent assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 10.23 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405642 | — | — | 1 | 10.70 |
| CHEMBL5434365 | — | — | 1 | 10.40 |
| CHEMBL5416427 | — | — | 1 | 10.10 |
| CHEMBL5436904 | — | — | 1 | 10.10 |
| CHEMBL5409068 | — | — | 1 | 10.05 |
| CHEMBL5419814 | — | — | 1 | 10.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405642 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL5434365 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL5416427 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL5436904 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL5409068 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL5419814 | — | IC50 | = | 0.1 | nM | 10.00 |