Assay Detail
Binding
CHEMBL5365371
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Displacement of [3H]-5HT from human 5-HT2B receptor expressed in african green monkey COS7 cells assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.67 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.14 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 8.05 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 7.37 |
| CHEMBL621 | TRAZODONE | 4.0 | 1 | 7.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL6437 | MIANSERIN | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL621 | TRAZODONE | Ki | = | 74.0 | nM | 7.13 |