Assay Detail
Binding
CHEMBL5365375
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Displacement of [3H]-LSD from human 5-HT2B receptor assessed as inhibition constant
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2B Determined: The Future of the Serotonin Receptor 2B in Drug Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.45 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3187365 | ASENAPINE | 4.0 | 1 | 9.68 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 9.44 |
| CHEMBL5425738 | — | — | 1 | 7.62 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3187365 | ASENAPINE | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL5425738 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL716 | QUETIAPINE | Ki | = | 86.0 | nM | 7.07 |