Assay Detail
Binding
CHEMBL5365558
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ABCG2 (unknown origin)-mediated mitoxantrone efflux
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Broad substrate specificity ATP-binding cassette transporter ABCG2 (CHEMBL5393) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibitors of ABCG2-mediated multidrug resistance: Lead generation through computer-aided drug design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.30 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488910 | — | — | 1 | 7.30 |
| CHEMBL3110289 | — | — | 1 | 7.00 |
| CHEMBL2011288 | — | — | 1 | 6.89 |
| CHEMBL3353414 | — | — | 1 | 6.64 |
| CHEMBL3110290 | — | — | 1 | 6.52 |
| CHEMBL3353417 | — | — | 1 | 6.51 |
| CHEMBL1957192 | — | — | 1 | 6.37 |
| CHEMBL5402034 | — | — | 1 | 6.37 |
| CHEMBL3110299 | — | — | 1 | 6.31 |
| CHEMBL3353415 | — | — | 1 | 6.31 |
| CHEMBL3353422 | — | — | 1 | 6.21 |
| CHEMBL1957193 | — | — | 1 | 6.10 |
| CHEMBL5433560 | — | — | 1 | 6.08 |
| CHEMBL3110292 | — | — | 1 | 6.02 |
| CHEMBL1957202 | — | — | 1 | 6.02 |
| CHEMBL3108796 | — | — | 1 | 6.00 |
| CHEMBL3110301 | — | — | 2 | 5.96 |
| CHEMBL3110291 | — | — | 1 | 5.96 |
| CHEMBL410316 | FUMITREMORGIN | — | 1 | 5.70 |
| CHEMBL5426744 | — | — | 1 | - |
| CHEMBL2436171 | — | — | 1 | - |
| CHEMBL5414883 | — | — | 1 | - |
| CHEMBL5434596 | — | — | 1 | - |
| CHEMBL5435211 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488910 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3110289 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2011288 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3353414 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3110290 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3353417 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1957192 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5402034 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL3110299 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3353415 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL3353422 | — | EC50 | = | 610.0 | nM | 6.21 |
| CHEMBL1957193 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5433560 | — | EC50 | = | 840.0 | nM | 6.08 |
| CHEMBL1957202 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3110292 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL3108796 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3110301 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL3110291 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL3110301 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL410316 | FUMITREMORGIN | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5435211 | — | EC50 | - | — | - | |
| CHEMBL5434596 | — | EC50 | - | — | - | |
| CHEMBL5414883 | — | EC50 | - | — | - | |
| CHEMBL2436171 | — | EC50 | - | — | - | |
| CHEMBL5426744 | — | EC50 | - | — | - |