Assay Detail
Toxicity
CHEMBL5365870
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Cytotoxicity against rat Bone marrow cell assessed as inhibition of cell growth with (R)-4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)-N-(3-chloropyridin-2-yl)-N-(piperidin-3-yl) benzamide as high potent effect standard by celltiter-glo assay
34
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Rattus norvegicus |
| Cell Type | Bone marrow cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 4.79 | 5.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4109308 | — | — | 1 | 5.49 |
| CHEMBL5436376 | — | — | 1 | 5.19 |
| CHEMBL5397401 | — | — | 2 | 5.14 |
| CHEMBL5394025 | — | — | 1 | 4.96 |
| CHEMBL5408894 | — | — | 1 | 4.90 |
| CHEMBL5408632 | — | — | 1 | 4.86 |
| CHEMBL4107804 | — | — | 1 | 4.74 |
| CHEMBL5401016 | — | — | 1 | 4.67 |
| CHEMBL5398982 | — | — | 2 | 4.66 |
| CHEMBL5417992 | — | — | 2 | 4.63 |
| CHEMBL4107559 | — | — | 1 | 4.57 |
| CHEMBL5406351 | — | — | 1 | 4.12 |
| CHEMBL5414767 | — | — | 1 | - |
| CHEMBL5440847 | — | — | 1 | - |
| CHEMBL5415107 | — | — | 1 | - |
| CHEMBL5427421 | — | — | 1 | - |
| CHEMBL5414978 | — | — | 1 | - |
| CHEMBL5407175 | — | — | 1 | - |
| CHEMBL5433750 | — | — | 1 | - |
| CHEMBL5431139 | — | — | 1 | - |
| CHEMBL5421898 | — | — | 1 | - |
| CHEMBL5400549 | — | — | 1 | - |
| CHEMBL5405461 | — | — | 1 | - |
| CHEMBL5406095 | — | — | 1 | - |
| CHEMBL5414972 | — | — | 1 | - |
| CHEMBL5420031 | — | — | 1 | - |
| CHEMBL5418395 | — | — | 1 | - |
| CHEMBL5403764 | — | — | 1 | - |
| CHEMBL5414993 | — | — | 1 | - |
| CHEMBL5403420 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4109308 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL5436376 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL5397401 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5397401 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL5394025 | — | IC50 | = | 10920.0 | nM | 4.96 |
| CHEMBL5408894 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL5408632 | — | IC50 | = | 13750.0 | nM | 4.86 |
| CHEMBL4107804 | — | IC50 | = | 18230.0 | nM | 4.74 |
| CHEMBL5401016 | — | IC50 | = | 21210.0 | nM | 4.67 |
| CHEMBL5398982 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5417992 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL4107559 | — | IC50 | = | 27060.0 | nM | 4.57 |
| CHEMBL5417992 | — | IC50 | = | 35600.0 | nM | 4.45 |
| CHEMBL5398982 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL5406351 | — | IC50 | = | 76600.0 | nM | 4.12 |
| CHEMBL5406095 | — | IC50 | - | — | - | |
| CHEMBL5400549 | — | IC50 | - | — | - | |
| CHEMBL5403420 | — | IC50 | - | — | - | |
| CHEMBL5431139 | — | IC50 | - | — | - | |
| CHEMBL5415107 | — | IC50 | - | — | - | |
| CHEMBL5414787 | — | IC50 | - | — | - | |
| CHEMBL5421898 | — | IC50 | - | — | - | |
| CHEMBL5414767 | — | IC50 | - | — | - | |
| CHEMBL5440847 | — | IC50 | - | — | - | |
| CHEMBL5427421 | — | IC50 | - | — | - | |
| CHEMBL5414978 | — | IC50 | - | — | - | |
| CHEMBL5407175 | — | IC50 | - | — | - | |
| CHEMBL5433750 | — | IC50 | - | — | - | |
| CHEMBL5414993 | — | IC50 | - | — | - | |
| CHEMBL5403764 | — | IC50 | - | — | - | |
| CHEMBL5418395 | — | IC50 | - | — | - | |
| CHEMBL5420031 | — | IC50 | - | — | - | |
| CHEMBL5405461 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL5414972 | — | IC50 | - | — | - |