Assay Detail
Binding
CHEMBL5366113
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal 6His-tagged full length NDM-1 (unknown origin) expressed in Escherichia coli BL21-DE3 using nitrocefin as substrate incubated for 15 mins followed by substrate addition by absorbance based microplate reader analysis
62
Total Activities
62
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Kinetics, Thermodynamics, and Structural Effects of Quinoline-2-Carboxylates, Zinc-Binding Inhibitors of New Delhi Metallo-β-lactamase-1 Re-sensitizing Multidrug-Resistant Bacteria for Carbapenems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 62 | 5.85 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436058 | — | — | 1 | 6.68 |
| CHEMBL5434850 | — | — | 1 | 6.64 |
| CHEMBL5429713 | — | — | 1 | 6.60 |
| CHEMBL5421632 | — | — | 1 | 6.55 |
| CHEMBL5421999 | — | — | 1 | 6.54 |
| CHEMBL5409968 | — | — | 1 | 6.54 |
| CHEMBL5425851 | — | — | 1 | 6.52 |
| CHEMBL5434080 | — | — | 1 | 6.43 |
| CHEMBL5436857 | — | — | 1 | 6.43 |
| CHEMBL5424619 | — | — | 1 | 6.39 |
| CHEMBL5394233 | — | — | 1 | 6.36 |
| CHEMBL5423672 | — | — | 1 | 6.36 |
| CHEMBL5418994 | — | — | 1 | 6.35 |
| CHEMBL5426105 | — | — | 1 | 6.34 |
| CHEMBL5432742 | — | — | 1 | 6.33 |
| CHEMBL5425950 | — | — | 1 | 6.32 |
| CHEMBL5393815 | — | — | 1 | 6.30 |
| CHEMBL5416932 | — | — | 1 | 6.28 |
| CHEMBL5408328 | — | — | 1 | 6.27 |
| CHEMBL5415172 | — | — | 1 | 6.25 |
| CHEMBL5408921 | — | — | 1 | 6.17 |
| CHEMBL5402652 | — | — | 1 | 6.15 |
| CHEMBL5397784 | — | — | 1 | 6.15 |
| CHEMBL5417195 | — | — | 1 | 6.12 |
| CHEMBL5405077 | — | — | 1 | 6.08 |
| CHEMBL5426400 | — | — | 1 | 6.05 |
| CHEMBL5427511 | — | — | 1 | 6.02 |
| CHEMBL5435754 | — | — | 1 | 6.00 |
| CHEMBL5414788 | — | — | 1 | 5.89 |
| CHEMBL5430671 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436058 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5434850 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5429713 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5421632 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5421999 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5409968 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5425851 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5434080 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5436857 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5424619 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5394233 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5423672 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5418994 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5426105 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5432742 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5425950 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL5393815 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5416932 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5408328 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL5415172 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL5408921 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5402652 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5397784 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL5417195 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL5405077 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL5426400 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5427511 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5435754 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5414788 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5430671 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL5436726 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5422140 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL5412136 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL1321754 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5439532 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL5432778 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5423006 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL86754 | IODOQUINOL | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL497 | CLIOQUINOL | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL223448 | BROXYQUINOLINE | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1200596 | CHLOROXINE | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL5418575 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL284104 | DIPICOLINIC ACID | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5404428 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1368601 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL5265803 | — | IC50 | = | 11200.0 | nM | 4.95 |
| CHEMBL5279638 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL5413714 | — | IC50 | = | 17600.0 | nM | 4.75 |
| CHEMBL5415337 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL5437131 | — | IC50 | = | 27800.0 | nM | 4.56 |