Assay Detail
Functional
CHEMBL5366514
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Antiinflammatory activity against LPS-stimulated mouse primary peritoneal macrophage assessed as reduction in IL-6 level pretreated with compound for 22 hrs followed by LPS-induction and measured after 2 hrs by ELISA analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Peritoneal macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Highly Selective and Orally Bioavailable PI3Kδ Inhibitors with Anti-Inflammatory Activity for Treatment of Acute Lung Injury.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.36 | 5.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5405825 | — | — | 1 | 5.84 |
| CHEMBL5423819 | — | — | 1 | 5.35 |
| CHEMBL5412839 | — | — | 1 | 5.34 |
| CHEMBL5396838 | — | — | 1 | 5.30 |
| CHEMBL5395433 | — | — | 1 | 5.29 |
| CHEMBL5439852 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5405825 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL5423819 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL5412839 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL5396838 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL5395433 | — | IC50 | = | 5150.0 | nM | 5.29 |
| CHEMBL5439852 | — | IC50 | = | 9140.0 | nM | 5.04 |