Assay Detail
Binding
CHEMBL5366935
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse DPP-4 using Gly-Pro-AMC as substrate measured after 5 mins by CF assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Long-Acting Dipeptidyl Peptidase-4 Inhibitors: Structural Evolution and Long-Acting Determinants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.40 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | 4.0 | 1 | 9.92 |
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | 4.0 | 1 | 8.72 |
| CHEMBL376359 | ALOGLIPTIN | 4.0 | 1 | 8.07 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.70 |
| CHEMBL142703 | VILDAGLIPTIN | 4.0 | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237500 | LINAGLIPTIN | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL385517 | SAXAGLIPTIN ANHYDROUS | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL376359 | ALOGLIPTIN | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL142703 | VILDAGLIPTIN | IC50 | = | 26.0 | nM | 7.58 |