Assay Detail
Binding
CHEMBL5367007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NOX2 in human PLB-985 cells assessed as inhibition of PMA-induced hydrogen peroxide production pretreated for 15 mins followed by PMA stimulation and measured after 10 mins by Amplex Red based fluorescence analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PLB-985 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
NADPH Oxidases: From Molecular Mechanisms to Current Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.62 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | — | 1 | 7.00 |
| CHEMBL301982 | CELASTROL | — | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL397686 | DIPHENYLENEIODONIUM CHLORIDE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL301982 | CELASTROL | IC50 | = | 590.0 | nM | 6.23 |