Assay Detail
Functional
CHEMBL5367529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse Ba/F3 EGFR-V769_D770insASV cells incubated for 3 days by Cell Titer-Glo assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Ba/F3 EGFR-V769_D770insASV |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural Mechanism and Inhibitors Targeting EGFR Exon 20 Insertion (Ex20ins) Mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.19 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650281 | CLN-081 | 3.0 | 1 | 8.30 |
| CHEMBL4650319 | MOBOCERTINIB | 4.0 | 1 | 7.96 |
| CHEMBL5314564 | SUNVOZERTINIB | 3.0 | 1 | 7.66 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.34 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 6.76 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.41 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650281 | CLN-081 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4650319 | MOBOCERTINIB | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL5314564 | SUNVOZERTINIB | IC50 | = | 22.1 | nM | 7.66 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL939 | GEFITINIB | IC50 | = | 388.0 | nM | 6.41 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 1340.0 | nM | 5.87 |