Compound Detail

CHEMBL5314564

SUNVOZERTINIB

🧪 Phase III

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🧪 Phase III

C=CC(=O)Nc1cc(Nc2nccc(Nc3cc(Cl)c(F)cc3C(C)(C)O)n2)c(OC)cc1N1CC[C@@H](N(C)C)C1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL5314564
Name	SUNVOZERTINIB
Phase	Phase III
Structure Type	MOL
InChI Key	BTMKEDDEMKKSEF-QGZVFWFLSA-N

Known Names

122507 A-1801 A1801 ASYM-122507 DZ'0586 DZ-0586 DZ00000586 DZ0586 DZD-9008 Dzd9008 Sunvozertinib

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Molecular Properties

584.1

MW (Da)

5.26

ALogP

HBA

HBD

114.9

PSA (Å²)

0.24

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Chirality	Single Enantiomer

USAN Stem	-tinib
USAN Year	2022

Extended Properties

Molecular Formula	C29H35ClFN7O3
MW	584.10
Aromatic Rings	3
Heavy Atoms	41
NP-Likeness	-1.24

Indications

Carcinoma, Non-Small-Cell Lung Liver Diseases Lymphoma, Follicular

Activity Summary

IC50 3 meas. best 7.9

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
BaF3 CHEMBL614524	IC50	7.9	7.9	12.7	1
Unchecked CHEMBL612545	IC50	7.66	7.595	22.1	2

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
BaF3	IC50	=	12.7	nM	7.9	Antiproliferative activity against mouse BaF3 cells harboring wild type EGFR inc...	37669428
Unchecked	IC50	=	22.1	nM	7.66	Antiproliferative activity against mouse Ba/F3 EGFR-V769_D770insASV cells incuba...	37669428
Unchecked	IC50	=	29.6	nM	7.53	Antiproliferative activity against mouse Ba/F3 EGFR-H773-V774ins_NPH cells incub...	37669428

Literature References

PubMed	DOI	Target Context	# Activities
37669428	10.1021/acs.jmedchem.3c00875	Unchecked	3
37669428	10.1021/acs.jmedchem.3c00875	BaF3	1
37669428	10.1021/acs.jmedchem.3c00875	ADMET	1

Data from ChEMBL 36 via Core Engine