Assay Detail
Functional
CHEMBL5367531
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring EGFR-D770-N771insNPG mutant incubated for 3 days by Cell Titer-Glo assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structural Mechanism and Inhibitors Targeting EGFR Exon 20 Insertion (Ex20ins) Mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.85 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650319 | MOBOCERTINIB | 4.0 | 1 | 8.37 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.40 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 7.24 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.63 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650319 | MOBOCERTINIB | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2500.0 | nM | 5.60 |