Assay Detail
Functional
CHEMBL5367570
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Cytotoxicity against human U2932 cells assessed as inhibition of cell growth measured after 72 hrs by CCK-8 assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U2932 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Degradation of Cyclin-Dependent Kinase 9/Cyclin T1 by Optimized Microtubule-Associated Protein 1 Light Chain 3 Beta-Recruiting Coumarin Analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.72 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5406266 | — | — | 1 | 7.35 |
| CHEMBL5416120 | — | — | 1 | 7.35 |
| CHEMBL5426640 | — | — | 1 | 7.01 |
| CHEMBL5419105 | — | — | 1 | 6.98 |
| CHEMBL5435730 | — | — | 1 | 6.96 |
| CHEMBL5423578 | — | — | 1 | 6.92 |
| CHEMBL5422489 | — | — | 1 | 6.91 |
| CHEMBL5429025 | — | — | 1 | 6.90 |
| CHEMBL5439744 | — | — | 1 | 6.88 |
| CHEMBL5401799 | — | — | 1 | 6.85 |
| CHEMBL5438280 | — | — | 1 | 6.84 |
| CHEMBL5428548 | — | — | 1 | 6.81 |
| CHEMBL5396930 | — | — | 1 | 6.80 |
| CHEMBL5416615 | — | — | 1 | 6.80 |
| CHEMBL5398656 | — | — | 1 | 6.75 |
| CHEMBL5401095 | — | — | 1 | 6.72 |
| CHEMBL4587232 | — | — | 1 | 6.51 |
| CHEMBL5401446 | — | — | 1 | 6.50 |
| CHEMBL5410057 | — | — | 1 | 6.46 |
| CHEMBL5412084 | — | — | 1 | 6.37 |
| CHEMBL5425849 | — | — | 1 | 6.34 |
| CHEMBL5404474 | — | — | 1 | 6.32 |
| CHEMBL5409373 | — | — | 1 | 6.27 |
| CHEMBL5427244 | — | — | 1 | 6.22 |
| CHEMBL5395821 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5406266 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5416120 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL5426640 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5419105 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL5435730 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL5423578 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5422489 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5429025 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL5439744 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL5401799 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL5438280 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL5428548 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL5396930 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5416615 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL5398656 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5401095 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL4587232 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL5401446 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5410057 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL5412084 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL5425849 | — | IC50 | = | 459.0 | nM | 6.34 |
| CHEMBL5404474 | — | IC50 | = | 484.0 | nM | 6.32 |
| CHEMBL5409373 | — | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL5427244 | — | IC50 | = | 604.0 | nM | 6.22 |
| CHEMBL5395821 | — | IC50 | = | 624.0 | nM | 6.21 |