Assay Detail

CHEMBL5367834

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Binding

Inhibition of SYK (unknown origin)

ChEMBL ↗

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Target

Tyrosine-protein kinase SYK (CHEMBL2599) ↗

Open DB target context

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Tyrosine-protein kinase SYK (CHEMBL2599) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tyrosine-protein kinase SYK

CHEMBL2599

Anchored from Assay target.

Protein identity Tyrosine-protein kinase SYK

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

Tyrosine-protein kinase SYK (CHEMBL2599) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Oxetanes in Drug Discovery Campaigns.

Rojas JJ, Bull JA.
J Med Chem (2023) 66 : 12697 -12709
PubMed 37676858 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.00	8.21

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3986824	LANRAPLENIB	2.0	1	8.21
CHEMBL3265032	ENTOSPLETINIB	3.0	1	7.78

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3986824	LANRAPLENIB	IC50	=	6.2	nM	8.21
CHEMBL3265032	ENTOSPLETINIB	IC50	=	16.5	nM	7.78