Assay Detail
Binding
CHEMBL5368301
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Binding affinity to PBRM1 bromodomain 5 (unknown origin) assessed as dissociation constant by BROMOscan LeadHunter assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 26 | 6.99 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5415064 | — | — | 1 | 8.22 |
| CHEMBL5412292 | — | — | 1 | 8.05 |
| CHEMBL5424811 | — | — | 1 | 8.00 |
| CHEMBL5409404 | — | — | 1 | 7.72 |
| CHEMBL5401472 | — | — | 1 | 7.66 |
| CHEMBL5406315 | — | — | 1 | 7.62 |
| CHEMBL5398829 | — | — | 1 | 7.54 |
| CHEMBL5431862 | — | — | 1 | 7.44 |
| CHEMBL5177096 | — | — | 1 | 7.40 |
| CHEMBL5411199 | — | — | 1 | 7.40 |
| CHEMBL5428009 | — | — | 1 | 7.40 |
| CHEMBL5425250 | — | — | 1 | 7.28 |
| CHEMBL5396881 | — | — | 1 | 5.40 |
| CHEMBL5394310 | — | — | 1 | 4.96 |
| CHEMBL5426305 | — | — | 1 | 4.89 |
| CHEMBL5421138 | — | — | 1 | 4.82 |
| CHEMBL5399079 | — | — | 1 | - |
| CHEMBL5402159 | — | — | 1 | - |
| CHEMBL5395676 | — | — | 1 | - |
| CHEMBL5406457 | — | — | 1 | - |
| CHEMBL5415837 | — | — | 1 | - |
| CHEMBL5401735 | — | — | 1 | - |
| CHEMBL5431005 | — | — | 1 | - |
| CHEMBL5441040 | — | — | 1 | - |
| CHEMBL5415253 | — | — | 1 | - |
| CHEMBL5415396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5415064 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL5412292 | — | Kd | = | 9.0 | nM | 8.05 |
| CHEMBL5424811 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL5409404 | — | Kd | = | 19.0 | nM | 7.72 |
| CHEMBL5401472 | — | Kd | = | 22.0 | nM | 7.66 |
| CHEMBL5406315 | — | Kd | = | 24.0 | nM | 7.62 |
| CHEMBL5398829 | — | Kd | = | 29.0 | nM | 7.54 |
| CHEMBL5431862 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL5177096 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL5411199 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL5428009 | — | Kd | = | 40.0 | nM | 7.40 |
| CHEMBL5425250 | — | Kd | = | 53.0 | nM | 7.28 |
| CHEMBL5396881 | — | Kd | = | 3950.0 | nM | 5.40 |
| CHEMBL5394310 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL5426305 | — | Kd | = | 13000.0 | nM | 4.89 |
| CHEMBL5421138 | — | Kd | = | 15000.0 | nM | 4.82 |
| CHEMBL5399079 | — | Kd | > | 20000.0 | nM | - |
| CHEMBL5402159 | — | Kd | > | 20000.0 | nM | - |
| CHEMBL5395676 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5406457 | — | Kd | > | 20000.0 | nM | - |
| CHEMBL5415837 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5401735 | — | Kd | > | 10000.0 | nM | - |
| CHEMBL5431005 | — | Kd | > | 20000.0 | nM | - |
| CHEMBL5441040 | — | Kd | > | 20000.0 | nM | - |
| CHEMBL5415253 | — | Kd | > | 20000.0 | nM | - |
| CHEMBL5415396 | — | Kd | > | 20000.0 | nM | - |