Compound Detail
CHEMBL5441040
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Basic Information
| ChEMBL ID | CHEMBL5441040 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YSOVTDFGNDCQKR-JTQLQIEISA-N |
4
Targets
4
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
258.3
MW (Da)
2.70
ALogP
5
HBA
1
HBD
68.2
PSA (Ų)
0.92
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 3 meas. best 6.36
EC50 1 meas. best 5.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein polybromo-1 CHEMBL1795184 | Kd | 6.36 | 6.36 | 440.0 | 1 |
| Probable global transcription activator SNF2L2 CHEMBL2362979 | Kd | 5.37 | 5.37 | 4300.0 | 1 |
| Nuclear receptor subfamily 1 group I member 2 CHEMBL3401 | EC50 | 5.06 | 5.06 | 8700.0 | 1 |
| Transcription activator BRG1 CHEMBL3085620 | Kd | 4.96 | 4.96 | 11000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein polybromo-1 | Kd | = | 440.0 | nM | 6.36 | Binding affinity to PBRM1 bromodomain 2 (unknown origin) assessed as dissociatio... | 37702400 |
| Probable global transcription activator SNF2L2 | Kd | = | 4300.0 | nM | 5.37 | Binding affinity to SMARCA2 (unknown origin) assessed as dissociation constant b... | 37702400 |
| Nuclear receptor subfamily 1 group I member 2 | EC50 | = | 8700.0 | nM | 5.06 | Agonist activity at PXR (unknown origin) by cellular reporter assay | 37702400 |
| Transcription activator BRG1 | Kd | = | 11000.0 | nM | 4.96 | Binding affinity to SMARCA4 (unknown origin) assessed as dissociation constant b... | 37702400 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37702400 | 10.1021/acs.jmedchem.3c01149 | Protein polybromo-1 | 2 |
| 37702400 | 10.1021/acs.jmedchem.3c01149 | Probable global transcription activator SNF2L2 | 1 |
| 37702400 | 10.1021/acs.jmedchem.3c01149 | Transcription activator BRG1 | 1 |
| 37702400 | 10.1021/acs.jmedchem.3c01149 | Nuclear receptor subfamily 1 group I member 2 | 1 |
| 37702400 | 10.1021/acs.jmedchem.3c01149 | Oxysterols receptor LXR-alpha | 1 |
| 37702400 | 10.1021/acs.jmedchem.3c01149 | Oxysterols receptor LXR-beta | 1 |
Data from ChEMBL 36 via Core Engine