Assay Detail
Binding
CHEMBL5368326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PXR (unknown origin) by cellular reporter assay
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 1 group I member 2 (CHEMBL3401) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
GNE-235: A Lead Compound Selective for the Second Bromodomain of PBRM1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.72 | 6.85 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5409404 | — | — | 1 | 6.85 |
| CHEMBL5406315 | — | — | 1 | 6.70 |
| CHEMBL5401472 | — | — | 1 | 6.07 |
| CHEMBL5415396 | — | — | 1 | 5.38 |
| CHEMBL5428009 | — | — | 1 | 5.32 |
| CHEMBL5441040 | — | — | 1 | 5.06 |
| CHEMBL5426305 | — | — | 1 | 4.66 |
| CHEMBL5421138 | — | — | 1 | - |
| CHEMBL5431005 | — | — | 1 | - |
| CHEMBL3752911 | — | — | 1 | - |
| CHEMBL5207330 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5409404 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5406315 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5401472 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5415396 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL5428009 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL5441040 | — | EC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL5426305 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL5421138 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL5431005 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL3752911 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5207330 | — | Activity | - | — | - |