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Assay Detail

CHEMBL5368491

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1 IIIB infected in human MT2 cells assessed as inhibition of viral growth incubated for 30 mins by ELISA assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Cell Type MT2
Confidence 1 — Organism
Curated By Autocuration

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Rational Design of Sulfonyl-γ-AApeptides as Highly Potent HIV-1 Fusion Inhibitors with Broad-Spectrum Activity.
Xue S, Xu W, Wang L, Xu L, Calcul L, Teng P, Lu L, Jiang S, Cai J.
J Med Chem (2023) 66 : 13319 -13331
PubMed 37706450 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.84 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5434714 1 9.00
CHEMBL5413691 1 6.75
CHEMBL5429297 1 6.01
CHEMBL5398828 1 5.40
CHEMBL5412301 1 4.80
CHEMBL5416675 1 4.52
CHEMBL5422940 1 4.41
CHEMBL5426679 1 -
CHEMBL5423860 1 -
CHEMBL5395054 1 -
CHEMBL5400616 1 -
CHEMBL5438182 1 -
CHEMBL5404762 1 -
CHEMBL5438289 1 -
CHEMBL5409825 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5434714 IC50 = 1.0 nM 9.00
CHEMBL5413691 IC50 = 180.0 nM 6.75
CHEMBL5429297 IC50 = 980.0 nM 6.01
CHEMBL5398828 IC50 = 4000.0 nM 5.40
CHEMBL5412301 IC50 = 15720.0 nM 4.80
CHEMBL5416675 IC50 = 30000.0 nM 4.52
CHEMBL5422940 IC50 = 38930.0 nM 4.41
CHEMBL5426679 IC50 > 40000.0 nM -
CHEMBL5423860 IC50 > 40000.0 nM -
CHEMBL5395054 IC50 > 40000.0 nM -
CHEMBL5400616 IC50 > 40000.0 nM -
CHEMBL5438182 IC50 > 100000.0 nM -
CHEMBL5404762 IC50 > 100000.0 nM -
CHEMBL5438289 IC50 > 100000.0 nM -
CHEMBL5409825 IC50 > 100000.0 nM -