Assay Detail
Functional
CHEMBL5368494
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 CRF02_AG Clone 278 clinical isolate infected in human TZM-bl cells assessed as inhibition of viral growth incubated for 48 hrs by luciferase based analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Rational Design of Sulfonyl-γ-AApeptides as Highly Potent HIV-1 Fusion Inhibitors with Broad-Spectrum Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.27 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 1 | 7.55 |
| CHEMBL5413691 | — | — | 1 | 7.22 |
| CHEMBL5429297 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL525076 | ENFUVIRTIDE | IC50 | = | 28.4 | nM | 7.55 |
| CHEMBL5413691 | — | IC50 | = | 60.4 | nM | 7.22 |
| CHEMBL5429297 | — | IC50 | = | 89.0 | nM | 7.05 |