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Assay Detail

CHEMBL5368501

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to HIV1 GP41 using GP41 NHR derived N36 peptide assessed as binding constant by fluorescence polarization assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Envelope glycoprotein gp160 (CHEMBL6181)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Rational Design of Sulfonyl-γ-AApeptides as Highly Potent HIV-1 Fusion Inhibitors with Broad-Spectrum Activity.
Xue S, Xu W, Wang L, Xu L, Calcul L, Teng P, Lu L, Jiang S, Cai J.
J Med Chem (2023) 66 : 13319 -13331
PubMed 37706450 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 6.17 6.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5413691 1 6.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5413691 Kd = 670.0 nM 6.17