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Assay Detail

CHEMBL5368799

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Toxicity
Cytotoxicity against rat L6 cells assessed as cell growth inhibition incubated for 6 days by resazurin dye based assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Toxicity
Organism Rattus norvegicus
Cell Type L6
Confidence 1 — Organism
Curated By Autocuration

Target

L6 (CHEMBL614793)
Type CELL-LINE
Organism Rattus norvegicus

Publication

Bis-6-amidino-benzothiazole Derivative that Cures Experimental Stage 1 African Trypanosomiasis with a Single Dose.
Racané L, Ptiček L, Kostrun S, Raić-Malić S, Taylor MC, Delves M, Alsford S, Olmo F, Francisco AF, Kelly JM.
J Med Chem (2023) 66 : 13043 -13057
PubMed 37722077 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 21 4.75 5.61

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5417161 1 5.61
CHEMBL5416356 1 5.39
CHEMBL5405752 1 5.38
CHEMBL5420181 1 5.16
CHEMBL5394795 1 4.96
CHEMBL5425887 1 4.87
CHEMBL5396205 1 4.86
CHEMBL5396323 1 4.37
CHEMBL5432670 1 4.29
CHEMBL5415516 1 4.09
CHEMBL5412493 1 4.03
CHEMBL5416172 1 4.03
CHEMBL5400545 1 -
CHEMBL5396341 1 -
CHEMBL5404790 1 -
CHEMBL5410902 1 -
CHEMBL5416542 1 -
CHEMBL5430418 1 -
CHEMBL5399066 1 -
CHEMBL5401969 1 -
CHEMBL5430502 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5417161 EC50 = 2480.0 nM 5.61
CHEMBL5416356 EC50 = 4100.0 nM 5.39
CHEMBL5405752 EC50 = 4150.0 nM 5.38
CHEMBL5420181 EC50 = 6850.0 nM 5.16
CHEMBL5394795 EC50 = 10900.0 nM 4.96
CHEMBL5425887 EC50 = 13400.0 nM 4.87
CHEMBL5396205 EC50 = 13900.0 nM 4.86
CHEMBL5396323 EC50 = 42500.0 nM 4.37
CHEMBL5432670 EC50 = 51800.0 nM 4.29
CHEMBL5415516 EC50 = 80600.0 nM 4.09
CHEMBL5412493 EC50 = 93500.0 nM 4.03
CHEMBL5416172 EC50 = 93000.0 nM 4.03
CHEMBL5400545 EC50 = 114000.0 nM -
CHEMBL5396341 EC50 > 130000.0 nM -
CHEMBL5404790 EC50 > 130000.0 nM -
CHEMBL5410902 EC50 = 134000.0 nM -
CHEMBL5416542 EC50 > 150000.0 nM -
CHEMBL5430418 EC50 > 160000.0 nM -
CHEMBL5399066 EC50 > 130000.0 nM -
CHEMBL5401969 EC50 > 140000.0 nM -
CHEMBL5430502 EC50 > 170000.0 nM -