Assay Detail
Functional
CHEMBL5368989
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Antileishmanial activity against Leishmania donovani MHOM/ET/67/HU3 intracellular amastigotes infected in human THP-1 cells assessed as inhibition of parasite growth incubated for 72 hrs by resazurin based colorimetric assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania donovani |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Biophysical and Biological Studies of <i>N</i>-Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.03 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 6.72 |
| CHEMBL5396668 | — | — | 1 | 6.26 |
| CHEMBL5415696 | — | — | 1 | 6.19 |
| CHEMBL5405513 | — | — | 1 | 6.11 |
| CHEMBL5402794 | — | — | 1 | 6.04 |
| CHEMBL5418641 | — | — | 1 | 6.01 |
| CHEMBL5438251 | — | — | 1 | 5.96 |
| CHEMBL5416121 | — | — | 1 | 5.59 |
| CHEMBL5439900 | — | — | 1 | 5.38 |
| CHEMBL5395180 | — | — | 1 | - |
| CHEMBL5420686 | — | — | 1 | - |
| CHEMBL5436238 | — | — | 1 | - |
| CHEMBL5403847 | — | — | 1 | - |
| CHEMBL5418014 | — | — | 1 | - |
| CHEMBL5417618 | — | — | 1 | - |
| CHEMBL5402608 | — | — | 1 | - |
| CHEMBL5437728 | — | — | 1 | - |
| CHEMBL5422257 | — | — | 1 | - |
| CHEMBL5410436 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5396668 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5415696 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5405513 | — | EC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5402794 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5418641 | — | EC50 | = | 980.0 | nM | 6.01 |
| CHEMBL5438251 | — | EC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL5416121 | — | EC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL5439900 | — | EC50 | = | 4190.0 | nM | 5.38 |
| CHEMBL5395180 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5420686 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5436238 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5403847 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5418014 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5417618 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5402608 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5437728 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5422257 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL5410436 | — | EC50 | > | 10000.0 | nM | - |