Assay Detail
Binding
CHEMBL5369205
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Inhibition of c-Met (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel, Thienopyridine-Based Tyrosine Kinase Inhibitors Targeting Tumorigenic RON Splice Variants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.35 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 8.89 |
| CHEMBL5404435 | — | — | 1 | 8.40 |
| CHEMBL3545307 | MERESTINIB | 2.0 | 1 | 8.33 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 8.10 |
| CHEMBL445799 | — | — | 1 | 8.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5404435 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3545307 | MERESTINIB | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL445799 | — | IC50 | = | 9.0 | nM | 8.05 |