Assay Detail
Binding
CHEMBL5369546
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Inhibition of ROCK2 (unknown origin)
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 8.10 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5408482 | — | — | 1 | 8.92 |
| CHEMBL5437264 | — | — | 1 | 8.89 |
| CHEMBL5421280 | — | — | 1 | 8.85 |
| CHEMBL5428749 | — | — | 1 | 8.85 |
| CHEMBL5406146 | — | — | 1 | 8.82 |
| CHEMBL5438374 | — | — | 1 | 8.77 |
| CHEMBL5426560 | — | — | 1 | 8.72 |
| CHEMBL5400934 | — | — | 1 | 8.38 |
| CHEMBL5412156 | — | — | 1 | 8.16 |
| CHEMBL5422811 | — | — | 1 | 8.12 |
| CHEMBL5407182 | — | — | 1 | 8.11 |
| CHEMBL5428430 | — | — | 1 | 7.83 |
| CHEMBL5414576 | — | — | 1 | 7.79 |
| CHEMBL5404104 | — | — | 1 | 7.76 |
| CHEMBL5411877 | — | — | 1 | 7.46 |
| CHEMBL5440366 | — | — | 1 | 7.26 |
| CHEMBL5425811 | — | — | 1 | 6.61 |
| CHEMBL4595425 | — | — | 1 | 6.47 |
| CHEMBL5395510 | — | — | 1 | - |
| CHEMBL5405389 | — | — | 1 | - |
| CHEMBL5399312 | — | — | 1 | - |
| CHEMBL5430096 | — | — | 1 | - |
| CHEMBL5400666 | — | — | 1 | - |
| CHEMBL5407425 | — | — | 1 | - |
| CHEMBL5424919 | — | — | 1 | - |
| CHEMBL5398425 | — | — | 1 | - |
| CHEMBL5409113 | — | — | 1 | - |
| CHEMBL5405650 | — | — | 1 | - |
| CHEMBL5425278 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5408482 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL5437264 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL5421280 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5428749 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5406146 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL5438374 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL5426560 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL5400934 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL5412156 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5422811 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL5407182 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL5428430 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL5414576 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL5404104 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL5411877 | — | IC50 | = | 34.3 | nM | 7.46 |
| CHEMBL5440366 | — | IC50 | = | 54.7 | nM | 7.26 |
| CHEMBL5425811 | — | IC50 | = | 246.8 | nM | 6.61 |
| CHEMBL4595425 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL5395510 | — | IC50 | - | — | - | |
| CHEMBL5405389 | — | IC50 | - | — | - | |
| CHEMBL5399312 | — | IC50 | - | — | - | |
| CHEMBL5430096 | — | IC50 | - | — | - | |
| CHEMBL5400666 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5407425 | — | IC50 | - | — | - | |
| CHEMBL5424919 | — | IC50 | - | — | - | |
| CHEMBL5398425 | — | IC50 | - | — | - | |
| CHEMBL5409113 | — | IC50 | - | — | - | |
| CHEMBL5405650 | — | IC50 | - | — | - | |
| CHEMBL5425278 | — | IC50 | - | — | - |