Compound Detail
CHEMBL5425278
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Basic Information
| ChEMBL ID | CHEMBL5425278 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZEWYNSIYDWOSBM-VKLKMBQZSA-N |
| Parent Compound | CHEMBL5499618 |
| Active Moiety | CHEMBL5499618 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
406.5
MW (Da)
2.96
ALogP
5
HBA
2
HBD
68.2
PSA (Ų)
0.70
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.65
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N2a CHEMBL614062 | IC50 | 5.65 | 5.65 | 2230.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N2a | IC50 | = | 2230.0 | nM | 5.65 | Antiproliferative activity against mouse Neuro2a cells assessed as reduction in ... | 37749892 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37749892 | 10.1021/acs.jmedchem.3c00829 | N2a | 4 |
| 37749892 | 10.1021/acs.jmedchem.3c00829 | Rho-associated protein kinase 2 | 1 |
| 37749892 | 10.1021/acs.jmedchem.3c00829 | RAC-alpha serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine