Assay Detail
Functional
CHEMBL5369529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse Neuro2a cells assessed as reduction in cell viability incubated for 72 hrs by SRB assay
38
Total Activities
38
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | N2a |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.94 | 6.66 |
| Activity | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438374 | — | — | 1 | 6.66 |
| CHEMBL5421280 | — | — | 1 | 6.58 |
| CHEMBL5406146 | — | — | 1 | 6.54 |
| CHEMBL5399312 | — | — | 1 | 6.40 |
| CHEMBL5412156 | — | — | 1 | 6.35 |
| CHEMBL5404104 | — | — | 1 | 6.21 |
| CHEMBL5428430 | — | — | 1 | 6.16 |
| CHEMBL5405389 | — | — | 1 | 6.14 |
| CHEMBL5414576 | — | — | 1 | 6.12 |
| CHEMBL5400934 | — | — | 1 | 6.11 |
| CHEMBL5398425 | — | — | 1 | 6.06 |
| CHEMBL5407182 | — | — | 1 | 6.03 |
| CHEMBL5409113 | — | — | 1 | 5.98 |
| CHEMBL5405650 | — | — | 1 | 5.96 |
| CHEMBL5422811 | — | — | 1 | 5.95 |
| CHEMBL5411877 | — | — | 1 | 5.86 |
| CHEMBL5407425 | — | — | 1 | 5.82 |
| CHEMBL5395510 | — | — | 1 | 5.65 |
| CHEMBL5425278 | — | — | 1 | 5.65 |
| CHEMBL5424919 | — | — | 1 | 5.56 |
| CHEMBL5432522 | — | — | 1 | 5.21 |
| CHEMBL5430096 | — | — | 1 | 4.86 |
| CHEMBL5399565 | — | — | 1 | 4.80 |
| CHEMBL5424777 | — | — | 1 | - |
| CHEMBL5404131 | — | — | 1 | - |
| CHEMBL5423093 | — | — | 1 | - |
| CHEMBL5425319 | — | — | 1 | - |
| CHEMBL300138 | ENZASTAURIN | 3.0 | 1 | - |
| CHEMBL91829 | RUBOXISTAURIN | 3.0 | 1 | - |
| CHEMBL565612 | SOTRASTAURIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438374 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5421280 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5406146 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5399312 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5412156 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5404104 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL5428430 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5405389 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5414576 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL5400934 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5398425 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5407182 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5409113 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5405650 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL5422811 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL5411877 | — | IC50 | = | 1368.0 | nM | 5.86 |
| CHEMBL5407425 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL5395510 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL5425278 | — | IC50 | = | 2230.0 | nM | 5.65 |
| CHEMBL5424919 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL5432522 | — | IC50 | = | 6240.0 | nM | 5.21 |
| CHEMBL5430096 | — | IC50 | = | 13740.0 | nM | 4.86 |
| CHEMBL5399565 | — | IC50 | = | 15870.0 | nM | 4.80 |
| CHEMBL5440366 | — | IC50 | < | 630.0 | nM | - |
| CHEMBL5408482 | — | IC50 | < | 630.0 | nM | - |
| CHEMBL5426560 | — | IC50 | < | 630.0 | nM | - |
| CHEMBL5428749 | — | IC50 | < | 630.0 | nM | - |
| CHEMBL5437264 | — | IC50 | < | 630.0 | nM | - |
| CHEMBL5400666 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5425811 | — | IC50 | - | — | - | |
| CHEMBL5400932 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL565612 | SOTRASTAURIN | Activity | - | — | - | |
| CHEMBL91829 | RUBOXISTAURIN | Activity | - | — | - | |
| CHEMBL300138 | ENZASTAURIN | Activity | - | — | - | |
| CHEMBL5425319 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5423093 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5404131 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL5424777 | — | IC50 | > | 20000.0 | nM | - |