Assay Detail
Binding
CHEMBL5370010
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Binding affinity to pUC-19 plasmid DNA (unknown origin) assessed as DNA cleavage incubated for 30 mins in presence of BamHI restriction enzyme by ethidium bromide staining based agarose gel electrophoresis analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
DNA major versus minor groove occupancy of monomeric and dimeric crystal violet derivatives. Toward structural correlations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.72 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5423999 | — | — | 1 | 5.27 |
| CHEMBL5408621 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5423999 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL5408621 | — | IC50 | = | 67000.0 | nM | 4.17 |