Assay Detail
Functional
CHEMBL5370464
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Antiproliferative activity against human MOLM-13 cells assessed as cell growth inhibition incubated for 7 days by WST-8 assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Pyrrolo[2,3-<i>c</i>]pyridines as Potent and Reversible LSD1 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.89 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5436614 | — | — | 1 | 7.51 |
| CHEMBL5405014 | — | — | 1 | 7.24 |
| CHEMBL5407627 | — | — | 1 | 7.21 |
| CHEMBL5408486 | — | — | 1 | 6.90 |
| CHEMBL5410439 | — | — | 1 | 6.89 |
| CHEMBL5422998 | — | — | 1 | 6.77 |
| CHEMBL5410299 | — | — | 1 | 6.74 |
| CHEMBL5436979 | — | — | 1 | 6.50 |
| CHEMBL3134377 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5436614 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL5405014 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5407627 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5408486 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL5410439 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5422998 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5410299 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL5436979 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL3134377 | — | IC50 | = | 613.0 | nM | 6.21 |