Assay Detail
Binding
CHEMBL5370971
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Inhibition of DENV C-terminal histidine-tagged NS5/RNA-dependent RNA polymerase
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Dengue virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Perspectives on the current antiviral developments towards RNA-dependent RNA polymerase (RdRp) and methyltransferase (MTase) domains of dengue virus non-structural protein 5 (DENV-NS5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.62 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450522 | SOTETSUFLAVONE | — | 1 | 6.80 |
| CHEMBL291426 | HINOKIFLAVONE | — | 1 | 6.58 |
| CHEMBL63677 | ROBUSTAFLAVONE | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450522 | SOTETSUFLAVONE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL291426 | HINOKIFLAVONE | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL63677 | ROBUSTAFLAVONE | IC50 | = | 330.0 | nM | 6.48 |