Assay Detail
Functional
CHEMBL5371159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse BaF3 cells harboring FLT3 ITD/F691L mutant assessed as inhibition of cell growth incubated for 72 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.33 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 8.15 |
| CHEMBL4077071 | — | — | 1 | 7.25 |
| CHEMBL5401158 | — | — | 1 | 7.02 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 6.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4077071 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL5401158 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 133.0 | nM | 6.88 |