Assay Detail
Functional
CHEMBL5371161
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Antiproliferative activity against mouse BaF3 cells harboring FLT3 D835V mutant assessed as inhibition of cell growth incubated for 72 hrs
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rational design of 4-((6-phenoxypyrimidin-4-yl)amino)-N-(4-(piperazin-1-yl)phenyl)-1H-pyrazole-3-carboxamide (LT-540-717) as orally bioavailable FLT3 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.55 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 8.40 |
| CHEMBL4077071 | — | — | 1 | 7.41 |
| CHEMBL5401158 | — | — | 1 | 7.37 |
| CHEMBL576982 | QUIZARTINIB | 4.0 | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4077071 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL5401158 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL576982 | QUIZARTINIB | IC50 | = | 100.0 | nM | 7.00 |