Assay Detail
Binding
CHEMBL5371245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAO A in mouse GL26 cells preincubated for 20 mins followed by 14C-labeled 5-hydroxytryptamine addition and measured after 20 mins by scintillation counter analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | GL26 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.15 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | 9.00 |
| CHEMBL5420976 | — | — | 1 | 6.96 |
| CHEMBL5402850 | — | — | 1 | 6.07 |
| CHEMBL5440373 | — | — | 1 | 6.06 |
| CHEMBL5423568 | — | — | 1 | 5.75 |
| CHEMBL5411460 | — | — | 1 | 5.64 |
| CHEMBL5428605 | — | — | 1 | 5.63 |
| CHEMBL5414199 | — | — | 1 | 5.63 |
| CHEMBL5424270 | — | — | 1 | 5.41 |
| CHEMBL5426666 | — | — | 1 | 5.34 |
| CHEMBL5407826 | — | — | 1 | - |
| CHEMBL5424634 | — | — | 1 | - |
| CHEMBL5401636 | — | — | 1 | - |
| CHEMBL2103879 | GANETESPIB | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8706 | CLORGILINE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL5420976 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5402850 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL5440373 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5423568 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL5411460 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL5428605 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL5414199 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL5424270 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL5426666 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL5407826 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5424634 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5401636 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2103879 | GANETESPIB | IC50 | > | 10000.0 | nM | - |