Assay Detail
Binding
CHEMBL5371323
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Displacement of [3H]8-OH-DPAT from human 5-HT1A assessed as inhibition constant
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aporphines: A privileged scaffold in CNS drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.29 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25924 | — | — | 1 | 8.74 |
| CHEMBL284586 | — | — | 1 | 7.39 |
| CHEMBL417473 | — | — | 1 | 7.21 |
| CHEMBL28056 | — | — | 1 | 6.85 |
| CHEMBL283065 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25924 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL284586 | — | Ki | = | 40.7 | nM | 7.39 |
| CHEMBL417473 | — | Ki | = | 61.5 | nM | 7.21 |
| CHEMBL28056 | — | Ki | = | 142.0 | nM | 6.85 |
| CHEMBL283065 | — | Ki | = | 554.0 | nM | 6.26 |