Assay Detail
Binding
CHEMBL5371840
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human LRRK2 G2019S mutant measured after 60 mins by TR-FRET assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Leucine-rich repeat serine/threonine-protein kinase 2 (CHEMBL1075104) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-molecule LRRK2 inhibitors for PD therapy: Current achievements and future perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.45 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4303382 | — | — | 1 | 8.73 |
| CHEMBL2397014 | — | — | 1 | 8.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4303382 | — | IC50 | = | 1.85 | nM | 8.73 |
| CHEMBL2397014 | — | IC50 | = | 6.87 | nM | 8.16 |