Assay Detail
Functional
CHEMBL5371999
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Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.98 | 6.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438336 | — | — | 1 | 6.62 |
| CHEMBL5403110 | — | — | 1 | 6.43 |
| CHEMBL5414634 | — | — | 1 | 6.42 |
| CHEMBL5422446 | — | — | 1 | 6.36 |
| CHEMBL5397641 | — | — | 1 | 6.30 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 6.24 |
| CHEMBL5422542 | — | — | 1 | 6.24 |
| CHEMBL5421629 | — | — | 1 | 6.23 |
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 6.17 |
| CHEMBL5422080 | — | — | 1 | 6.14 |
| CHEMBL5395611 | — | — | 1 | 6.13 |
| CHEMBL5427507 | — | — | 1 | 6.13 |
| CHEMBL5433571 | — | — | 1 | 6.11 |
| CHEMBL5404665 | — | — | 1 | 6.11 |
| CHEMBL5440910 | — | — | 1 | 6.10 |
| CHEMBL5407909 | — | — | 1 | 6.09 |
| CHEMBL5396200 | — | — | 1 | 6.04 |
| CHEMBL5396043 | — | — | 1 | 6.03 |
| CHEMBL5432032 | — | — | 1 | 6.03 |
| CHEMBL5395438 | — | — | 1 | 6.03 |
| CHEMBL5420475 | — | — | 1 | 6.02 |
| CHEMBL5399155 | — | — | 1 | 6.00 |
| CHEMBL5437283 | — | — | 1 | 5.99 |
| CHEMBL5414903 | — | — | 1 | 5.98 |
| CHEMBL5411007 | — | — | 1 | 5.94 |
| CHEMBL5407855 | — | — | 1 | 5.94 |
| CHEMBL5397933 | — | — | 1 | 5.91 |
| CHEMBL5429434 | — | — | 1 | 5.86 |
| CHEMBL5401423 | — | — | 1 | 5.85 |
| CHEMBL5417266 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438336 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL5403110 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5414634 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5422446 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5397641 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5422542 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL5421629 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL5422080 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5395611 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5427507 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5433571 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5404665 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5440910 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5407909 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL5396200 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5395438 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5396043 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5432032 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5420475 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5399155 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL5437283 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL5414903 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5411007 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL5407855 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL5397933 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5429434 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL5401423 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL5417266 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL5411885 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL5417233 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5401008 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL5397062 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL5432604 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL5403489 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL339505 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL5433964 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL5431127 | — | IC50 | = | 4510.0 | nM | 5.35 |