Assay Detail
Functional
CHEMBL5372000
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.99 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438336 | — | — | 1 | 6.64 |
| CHEMBL5403110 | — | — | 1 | 6.57 |
| CHEMBL5414634 | — | — | 1 | 6.41 |
| CHEMBL5422446 | — | — | 1 | 6.35 |
| CHEMBL5422542 | — | — | 1 | 6.28 |
| CHEMBL5421629 | — | — | 1 | 6.28 |
| CHEMBL5395611 | — | — | 1 | 6.27 |
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 6.21 |
| CHEMBL5397641 | — | — | 1 | 6.20 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 6.19 |
| CHEMBL5422080 | — | — | 1 | 6.16 |
| CHEMBL5427507 | — | — | 1 | 6.13 |
| CHEMBL5404665 | — | — | 1 | 6.11 |
| CHEMBL5433571 | — | — | 1 | 6.10 |
| CHEMBL5399155 | — | — | 1 | 6.09 |
| CHEMBL5407909 | — | — | 1 | 6.06 |
| CHEMBL5420475 | — | — | 1 | 6.04 |
| CHEMBL5440910 | — | — | 1 | 6.04 |
| CHEMBL5396043 | — | — | 1 | 6.03 |
| CHEMBL5395438 | — | — | 1 | 6.03 |
| CHEMBL5396200 | — | — | 1 | 6.03 |
| CHEMBL5432032 | — | — | 1 | 6.02 |
| CHEMBL5414903 | — | — | 1 | 5.99 |
| CHEMBL5407855 | — | — | 1 | 5.97 |
| CHEMBL5437283 | — | — | 1 | 5.95 |
| CHEMBL5411007 | — | — | 1 | 5.89 |
| CHEMBL5397933 | — | — | 1 | 5.89 |
| CHEMBL5429434 | — | — | 1 | 5.85 |
| CHEMBL5401423 | — | — | 1 | 5.83 |
| CHEMBL5417266 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438336 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5403110 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5414634 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5422446 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5422542 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL5421629 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5395611 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL5397641 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5422080 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL5427507 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL5404665 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5433571 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL5399155 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL5407909 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5420475 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5440910 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5396200 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5395438 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5396043 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5432032 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL5414903 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL5407855 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5437283 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL5411007 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL5397933 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5429434 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL5401423 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL5417266 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL5417233 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL5411885 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL5397062 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL5401008 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL5432604 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL5403489 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL5433964 | — | IC50 | = | 3730.0 | nM | 5.43 |
| CHEMBL339505 | — | IC50 | = | 4230.0 | nM | 5.37 |
| CHEMBL5431127 | — | IC50 | = | 4600.0 | nM | 5.34 |