Assay Detail
Toxicity
CHEMBL5372002
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Cytotoxicity against human HDF cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | NHDF |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.76 | 6.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5438336 | — | — | 1 | 6.36 |
| CHEMBL5422446 | — | — | 1 | 6.36 |
| CHEMBL5403110 | — | — | 1 | 6.19 |
| CHEMBL5427507 | — | — | 1 | 6.11 |
| CHEMBL5421629 | — | — | 1 | 6.02 |
| CHEMBL5404665 | — | — | 1 | 6.01 |
| CHEMBL5414634 | — | — | 1 | 6.01 |
| CHEMBL5395611 | — | — | 1 | 6.00 |
| CHEMBL5422542 | — | — | 1 | 6.00 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 5.98 |
| CHEMBL5399155 | — | — | 1 | 5.93 |
| CHEMBL5440910 | — | — | 1 | 5.91 |
| CHEMBL5396200 | — | — | 1 | 5.90 |
| CHEMBL5397641 | — | — | 1 | 5.89 |
| CHEMBL5433571 | — | — | 1 | 5.82 |
| CHEMBL1554 | DACTINOMYCIN | 4.0 | 1 | 5.79 |
| CHEMBL5417266 | — | — | 1 | 5.77 |
| CHEMBL5437283 | — | — | 1 | 5.77 |
| CHEMBL5414903 | — | — | 1 | 5.76 |
| CHEMBL5395438 | — | — | 1 | 5.75 |
| CHEMBL5407909 | — | — | 1 | 5.75 |
| CHEMBL5422080 | — | — | 1 | 5.75 |
| CHEMBL5420475 | — | — | 1 | 5.74 |
| CHEMBL5397933 | — | — | 1 | 5.71 |
| CHEMBL5432032 | — | — | 1 | 5.69 |
| CHEMBL5396043 | — | — | 1 | 5.68 |
| CHEMBL5429434 | — | — | 1 | 5.68 |
| CHEMBL5411885 | — | — | 1 | 5.67 |
| CHEMBL5401423 | — | — | 1 | 5.66 |
| CHEMBL5411007 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5438336 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5422446 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5403110 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL5427507 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL5421629 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5404665 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5414634 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5395611 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL5422542 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL278315 | GELDANAMYCIN | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5399155 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL5440910 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL5396200 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL5397641 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL5433571 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL1554 | DACTINOMYCIN | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL5417266 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL5437283 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL5414903 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL5395438 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL5422080 | — | IC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL5407909 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL5420475 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL5397933 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL5432032 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL5396043 | — | IC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL5429434 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL5411885 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL5401423 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL5411007 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL5417233 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL5401008 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL5407855 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL5397062 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL5432604 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL5403489 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL5433964 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL5431127 | — | IC50 | = | 7440.0 | nM | 5.13 |
| CHEMBL339505 | — | IC50 | = | 7360.0 | nM | 5.13 |