Assay Detail
Binding
CHEMBL5372006
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Binding affinity to recombinant human HSP90alpha assessed as dissociation constant by isothermal titration calorimetry assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.33 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407855 | — | — | 1 | 5.41 |
| CHEMBL278315 | GELDANAMYCIN | 2.0 | 1 | 5.33 |
| CHEMBL5422446 | — | — | 1 | 5.31 |
| CHEMBL5438336 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407855 | — | Kd | = | 3860.0 | nM | 5.41 |
| CHEMBL278315 | GELDANAMYCIN | Kd | = | 4670.0 | nM | 5.33 |
| CHEMBL5422446 | — | Kd | = | 4930.0 | nM | 5.31 |
| CHEMBL5438336 | — | Kd | = | 5530.0 | nM | 5.26 |