Assay Detail
Binding
CHEMBL5372273
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SIRT5 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of 2,4,6- trisubstituted triazine derivatives as new nonpeptide small-molecule SIRT5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.59 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4091790 | — | — | 1 | 7.52 |
| CHEMBL5199472 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4091790 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5199472 | — | IC50 | = | 2200.0 | nM | 5.66 |