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Assay Detail

CHEMBL5372378

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HL-60 cells assessed as cell growth inhibition by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HL-60
Confidence 1 — Organism
Curated By Autocuration

Target

HL-60 (CHEMBL383)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic Ergosteroids from a Strain of the Fungus <i>Talaromyces adpressus</i>.
Zheng M, Xiao Y, Li Q, Lai Y, Dai B, Zhang M, Kang X, Tong Q, Wang J, Chen C, Zhu H, Zhang Y.
J Nat Prod (2023) 86 : 2081 -2090
PubMed 37676247 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.07 5.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL44657 ETOPOSIDE 4.0 1 5.68
CHEMBL250639 DANKASTERONE A 1 5.42
CHEMBL5403122 1 5.21
CHEMBL5438899 1 5.14
CHEMBL5432128 1 5.08
CHEMBL5403246 1 5.06
CHEMBL5397524 1 4.96
CHEMBL5438369 1 4.60
CHEMBL5435913 1 4.50
CHEMBL5423265 1 -
CHEMBL5439385 1 -
CHEMBL5412420 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL44657 ETOPOSIDE IC50 = 2100.0 nM 5.68
CHEMBL250639 DANKASTERONE A IC50 = 3800.0 nM 5.42
CHEMBL5403122 IC50 = 6100.0 nM 5.21
CHEMBL5438899 IC50 = 7300.0 nM 5.14
CHEMBL5432128 IC50 = 8300.0 nM 5.08
CHEMBL5403246 IC50 = 8800.0 nM 5.06
CHEMBL5397524 IC50 = 11000.0 nM 4.96
CHEMBL5438369 IC50 = 25000.0 nM 4.60
CHEMBL5435913 IC50 = 32000.0 nM 4.50
CHEMBL5423265 IC50 > 40000.0 nM -
CHEMBL5439385 IC50 > 40000.0 nM -
CHEMBL5412420 IC50 > 40000.0 nM -