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Assay Detail

CHEMBL5372990

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human Y4R expressed in CHO cells co-expressing Gqi5-mtAEQ assessed as dissociation constant preincubated for 20 mins under DPBS condition
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Neuropeptide Y receptor type 4 (CHEMBL4877)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

[<sup>3</sup>H]UR-JG102-A Radiolabeled Cyclic Peptide with High Affinity and Excellent Selectivity for the Neuropeptide Y Y<sub>4</sub> Receptor.
Gleixner J, Gattor AO, Humphrys LJ, Brunner T, Keller M.
J Med Chem (2023) 66 : 13788 -13808
PubMed 37773891 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 10.85 10.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5395013 1 10.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5395013 Kd = 0.014 nM 10.85