Assay Detail
Functional
CHEMBL5373035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human U-87 MG cells assessed as inhibition of cell proliferation incubated for 72 hrs by CellTiter-Glo luminescent assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-87MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.70 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223142 | SCHWEINFURTHIN G | — | 1 | 8.10 |
| CHEMBL5402401 | — | — | 1 | 8.03 |
| CHEMBL5399392 | — | — | 1 | 7.91 |
| CHEMBL223046 | VEDELIANIN | — | 1 | 7.82 |
| CHEMBL220472 | SCHWEINFURTHIN E | — | 1 | 7.66 |
| CHEMBL5396667 | — | — | 1 | 7.17 |
| CHEMBL5439741 | — | — | 1 | 7.11 |
| CHEMBL376007 | SCHWEINFURTHIN F | — | 1 | 7.01 |
| CHEMBL5416867 | — | — | 1 | 6.54 |
| CHEMBL5418635 | — | — | 1 | 6.47 |
| CHEMBL5409120 | — | — | 1 | 6.42 |
| CHEMBL5397075 | — | — | 1 | 6.38 |
| CHEMBL5394654 | — | — | 1 | 6.34 |
| CHEMBL5401329 | — | — | 1 | 6.32 |
| CHEMBL5433096 | — | — | 1 | 6.32 |
| CHEMBL5433829 | — | — | 1 | 6.30 |
| CHEMBL5417439 | — | — | 1 | 6.29 |
| CHEMBL411344 | SCHWEINFURTHIN H | — | 1 | 6.18 |
| CHEMBL5397623 | — | — | 1 | 5.83 |
| CHEMBL5414636 | — | — | 1 | 5.42 |
| CHEMBL515325 | MAPPAIN | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223142 | SCHWEINFURTHIN G | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL5402401 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL5399392 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL223046 | VEDELIANIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL220472 | SCHWEINFURTHIN E | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL5396667 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5439741 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL376007 | SCHWEINFURTHIN F | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL5416867 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL5418635 | — | IC50 | = | 336.0 | nM | 6.47 |
| CHEMBL5409120 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5397075 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5394654 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL5401329 | — | IC50 | = | 481.0 | nM | 6.32 |
| CHEMBL5433096 | — | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL5433829 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5417439 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL411344 | SCHWEINFURTHIN H | IC50 | = | 656.0 | nM | 6.18 |
| CHEMBL5397623 | — | IC50 | = | 1485.0 | nM | 5.83 |
| CHEMBL5414636 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL515325 | MAPPAIN | IC50 | = | 7000.0 | nM | 5.16 |