Assay Detail
Binding
CHEMBL5373345
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC6 in mouse LA-4 cells assessed as deacetylation of acetylated alpha-tubulin level incubated for 24 hrs by Western blot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | LA-4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Selective and Bioavailable HDAC6 2-(Difluoromethyl)-1,3,4-oxadiazole Substrate Inhibitors and Modeling of Their Bioactivation Mechanism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.20 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3935992 | — | — | 1 | 6.40 |
| CHEMBL5429808 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3935992 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL5429808 | — | IC50 | = | 1000.0 | nM | 6.00 |