Assay Detail
Binding
CHEMBL5373418
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Antagonist activity at URP-activated RLucII-tagged Galpha-i (unknown origin) expressed in HEK293 cells co-expressing human UT/GFP10-tagged G-gamma by BRET assay (Rvb = 7.10 +/- 0.19 No_unit)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Urotensin II Receptor Modulation with 1,3,4-Benzotriazepin-2-one Tetrapeptide Mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.86 | 6.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5421473 | — | — | 1 | 6.99 |
| CHEMBL5414487 | — | — | 1 | 6.83 |
| CHEMBL5416714 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5421473 | — | EC50 | = | 102.33 | nM | 6.99 |
| CHEMBL5414487 | — | EC50 | = | 147.91 | nM | 6.83 |
| CHEMBL5416714 | — | EC50 | = | 177.83 | nM | 6.75 |