Assay Detail
Binding
CHEMBL5373955
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Agonist activity at mouse TLR4 in human HEK-Blue mTLR4 cells assessed as NF-kappaB activation incubated for 48 hrs by SEAP reporter gene based Quanti-blue assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK-Blue mTLR4 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Diamino Allose Phosphates: Novel, Potent, and Highly Stable Toll-like Receptor 4 Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 9.16 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5407900 | — | — | 1 | 9.82 |
| CHEMBL5423611 | — | — | 1 | 9.72 |
| CHEMBL5432710 | — | — | 1 | 9.43 |
| CHEMBL5428754 | — | — | 1 | 9.37 |
| CHEMBL5433813 | — | — | 1 | 9.30 |
| CHEMBL5407887 | — | — | 1 | 9.17 |
| CHEMBL5417929 | — | — | 1 | 8.85 |
| CHEMBL5422378 | — | — | 1 | 8.58 |
| CHEMBL5434803 | — | — | 1 | 8.18 |
| CHEMBL507938 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5407900 | — | EC50 | = | 0.15 | nM | 9.82 |
| CHEMBL5423611 | — | EC50 | = | 0.19 | nM | 9.72 |
| CHEMBL5432710 | — | EC50 | = | 0.37 | nM | 9.43 |
| CHEMBL5428754 | — | EC50 | = | 0.43 | nM | 9.37 |
| CHEMBL5433813 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL5407887 | — | EC50 | = | 0.68 | nM | 9.17 |
| CHEMBL5417929 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL5422378 | — | EC50 | = | 2.64 | nM | 8.58 |
| CHEMBL5434803 | — | EC50 | = | 6.54 | nM | 8.18 |
| CHEMBL507938 | — | EC50 | = | 0.005 | nM | - |